CTSI Workshop
“Identifying Issues in the Responsible Conduct of Research,”
Karen Schmidt;
7039 Forbes Twr., noon

ADRC Lecture
“Recollection of Details in Mild Cognitive Impairment,”
Mark Wheeler, psychology;
S439 Montefiore, noon

Panther Advocate Medical Plan Option Info Session
1103 Scaife, 12:10-12:50 pm & 1:10-1:50 pm
(register: www2.hr.pitt.edu/PantherAdvocate/default.aspx)

Provost’s Inaugural Lecture
“And the Winner Is … Reflections on Assistive Technology,”
Michael Boninger, medicine;
Scaife lect. rm. 6, 4 pm

Friday 17

• Summer term add/drop period ends.

Bike to Campus Event
Free bike registration, safety check, raffle;
S. Bouquet side of Posvar, 8-10 am

Endocrine Grand Rounds
“Remission of Type 2 Diabetes in the Obese,”
David Rometo;
1195 BST, 8:30 am
(kal134@pitt.edu)

Senate Budget Policies Committee Meeting
156 CL, 1:10 pm

Sunday 19

Episcopal Service
Heinz Chapel, 11 am
(Sundays: http://pittepiscopalchaplaincy.wordpress.com/)

Monday 20

• Summer 12-week session add/drop period ends.

Panther Advocate Medical Plan Option Info Session
548 WPU, 12:10-12:50 pm & 1:10-1:50 pm
(register: www2.hr.pitt.edu/PantherAdvocate/default.aspx)

Chemistry Seminar
“Strategies & Tactics Inspired by Complex Alkaloids I,”
Richmond Sarpong, UC-Berkeley;
150 Chevron, 4 pm
(chemrcpt@pitt.edu)

Tuesday 21

Primary Election Day Voting
7 am-8 pm (www.votespa.com)

Senate Community Relations Committee Mtg.
272 Hillman, noon-2 pm

Basic & Translational Research Seminar
“Mechanism of Function of Neurotransmitter Transporters: Learning From Theory, Computations & Experiments,”
Ivet Bahar, medicine;
Hillman Cancer Ctr. Cooper classrm. D, noon
(toyg@upmc.edu)

MMR Seminar
“B Cell & Autoantibody Correlates of Clinical Responsiveness in Patients With Autoimmune Disorders After B Cell Depletion With Rituximab (anti-CD20) Therapy,”
Marc Levesque, medicine;
Rangos Research Ctr. aud., noon
(linda.cherok@chp.edu)

HSLS Workshop
“PowerPoint for Conf. Posters,”
Julie Jankovic;
Falk Library classrm. 2, 12:30-2:30 pm
(jcj6@pitt.edu)

Chemistry Seminar
“Strategies & Tactics Inspired by Complex Alkaloids II,”
Richmond Sarpong, UC-Berkeley;
150 Chevron, 2:30 pm
(chemrcpt@pitt.edu)

Provost’s Inaugural Lecture
“Reflections on the Field of Women’s Imaging,”
Jules Sumkin, medicine;
Scaife lect. rm. 6, 4 pm

Wednesday 22

Clinical Oncology & Hematology Grand Rounds
“Combinatorial Approaches to Melanoma Therapy,”
Hussein Tawbi, medicine;
Herberman conf. ctr. 2nd. fl. aud., 8 am
(millerc5@upmc.edu)

HSLS Workshop
“Painless PubMed,”
Melissa Ratakeski;
Falk Library classrm. 1, 10:30 am
(mar@pitt.edu)

Pathology Seminar
“Sequential Molecular Interactions That Regulate Leukocyte Transendothelial Migration: Studies in Vitro & in Vivo,”
William Muller, Northwestern;
S100 BST, noon
(http://path.upmc.edu/showcase/schedules/seminars/05222013.pdf)

CTSI Seminar
“Working Toward Solutions in IRB Protocol Design,”
Shannon Valenti;
4127 Sennott, noon
(www.ctsi.pitt.edu/CTSI_EventsArchive.aspx)

Oral & Maxillofacial Surgery Lecture
“Implants”;
G33 Salk, 4 pm
(also May 29; fordam@upmc.edu)

State of the Medical School Address
“Faculty Performance: Opportunities in a Time of Threats,”
Dean & Sr. VC Arthur Levine;
Scaife lect. rm. 5 & 6, 4:30 pm
(www.medschool.pitt.edu)

Friday 24

CTSI Workshop
“Everything You Ever Wanted to Know About DSMPs & DSMBs,”
Laurel Yasko;
S120 BST, 10 am
(http://www.ctsi.pitt.edu/registration.aspx?number=40)

EOH Seminar
“Epithelial Immunity in Airway Diseases,”
Yin Chen, pharmacology & toxicology;
540 Bridgeside Point, noon
(beagle@pitt.edu)

Saturday 25

• Official date for degrees awarded in the School of Law and the first professional programs in the medical and dental medicine schools.

Monday 27

• University closed for Memorial Day.

Tuesday 28

MMR Seminar
“Perturbed RNA-Binding Protein Function in ALS & FTLD: Lessons From FUS Models,”
Udai Pandey, LSU;
Rangos Research Ctr. aud., noon
(linda.cherok@chp.edu)

Wednesday 29

• Last day to submit withdrawal forms to dean’s office.

Clinical Oncology & Hematology Grand Rounds
“STAT3 in Acute Myeloid Leukemia & T-regulatory Cell Function Analysis in Locally/Regionally Advanced Melanoma Patients Treated With Ipilimumab,”
Kathleen Dorritie;
Herberman 2nd. fl. aud., 8 am
(millerc5@upmc.edu)

CTSI Seminar
“Informing Patients About Their Data From Clinical Research Studies: Clinical, Ethical & Measurement Considerations,”
Greg Seigle;
7039 Forbes Twr., 1 pm
(www.ctsi.pitt.edu/CTSI_EventsArchive.aspx)

HSLS Workshop
“Gene Regulation Resources,”
Ansuman Chattopadhyay;
Falk Library classrm. 2, 1-3 pm
(ansuman@pitt.edu)

Thursday 30

Pathology Fetterman Lecture
“Current Approach to the Infant With Inherited Anemia,”
Patrick Gallagher, Yale;
3rd fl. conf. rm. Rangos, 8 am
(http://path.upmc.edu/showcase/schedules/seminars/05302013.pdf)

HSLS Workshop
“Painless PubMed,”
Rebecca Abromitis;
Falk Library classrm. 1, 11 am
(baa@pitt.edu)

Chemistry Seminar
“Sulfur & Indole: Old Friends, New Methods,”
Jimmy Wu, Dartmouth;
150 Chevron, 2:30 pm
(chemrcpt@pitt.edu)

HSLS Workshop
“EndNote Basics,”
Linda Hartman;
Falk Library classrm. 2, 2:30-4:30 pm
(lhartman@pitt.edu)

Defenses

Law/Juridical Science
“The Role of Muslim Religious Institutions in Post-revolution Arab Countries & the Transition Toward Democracy: Egypt as a Case Study,”
Abdullah Alaoudh;
May 16, 120 Barco, 9 am

A&S/Linguistics
“Analyzing Instruction & Learning of Derivational Morphology in the Spanish Foreign Language Classroom,”
Nausica Marcos Miguel;
May 20, 2818 CL, 10 am

A&S/Biological Sciences
“Alk1 Signaling in Vascular Development,”
Derek Laux;
May 20, A219B Langley, noon

Medicine/Cell Biology & Molecular Physiology
“Modulation of Endocytic & Exocytic Traffic in Polarized Epithelial Cells,”
Christina Szalinski;
May 20, S123 BST, 2 pm

GSPH/Epidemiology
“Cost-Effectiveness of Implementing the Interventions for Diabetes Prevention & Control in the Community & Military Settings,”
Shihchen Kuo;
May 22, 222 Parkvale, 2 pm

A&S/Biological Sciences
“Unraveling Mechanisms of Transcriptional Repression: Novel Insights From Brinker,”
Priyanka Upadhyai;
May 29, A219B Langley, 10 am

A&S/Classics
“An Aristocracy of Virtue: The Protagorean Background to the Periclean Funeral Speech in Thucydides,”
Joseph Tipton;
May 29, 1518 CL, 2 pm

A&S/Linguistics
“The Preemption of Competition Through Instruction: Promoting the Acquisition of Case in Spanish Pronominal Object Clitics Through Classroom Instruction,”
Mickael Olsen;
May 29, 2816 CL, 2 pm

Exhibits

Barco Law Library
“The Art of Japanese Noh Drama,”
Tsukioka Kogyo;
Barco law lib., through May 17, Th 7 am-10 pm, F 7 am-8 pm

Deadlines

OMET Survey Request
Request student opinion of teaching survey; deadlines vary by session.
(omet.pitt.edu)

Greensburg Summer Day Camp in Career Exploration
Registration deadline is May 31.
(www.greensburg.pitt.edu/quest)

Basic to Clinical Collaborative Research Pilot Program
Submission deadline is June 15.
(www.ctsi.pitt.edu/documents/BaCCoR.pdf)

Event Deadline

The next issue of the University Times will include University and on-campus events of May 30-June 13. Information for events during that period must be received by 5 pm on May 23 at 308 Bellefield Hall. Information may be sent by fax to 4-4579 or email to utcal@pitt.edu.

###

The University Times events calendar includes Pitt-sponsored events as well as non-Pitt events held on a Pitt campus. Each events calendar covers a two-week period; material must be submitted one week prior to publication.

For deadlines, see the current publication schedule.

Information submitted for the calendar should identify the type of event, such as lecture or concert, and the program’s specific title, sponsor, location and time. The name and phone number of a contact person should be included. Information should be sent by email to: utcal@pitt.edu, by FAX to: 412/624-4579, or by campus mail to: 308 Bellefield Hall. We cannot guarantee publication of events received after the deadline.

A faculty group has joined an evaluation and training project, supported by a $2.6 million contract from the United States Agency for International Development (USAID), to examine West African communities where crime, unemployment and religious extremism are high and government effectiveness is low.

The governance group in the University’s Ford Institute for Human Security has partnered with The Mitchell Group, a Washington, D.C.-based research firm. The team also will help teach program-evaluation skills to West African professionals working in civic and humanitarian organizations.

The Pitt-Mitchell Group will analyze USAID’s Peace through Development program in Niger, Burkina Faso and Chad, which is working to help communities threatened by violent extremist groups. In addition, the team will assess USAID programs aiming to improve post-conflict social cohesion in Cote d’Ivoire, early warning signs of regional conflict throughout West Africa and natural resources transparency in Niger. They will carry out research projects on political violence, party development and other regional matters and manage a fellowship program for citizens of Burkina Faso, Chad and Niger to develop their own research projects.

Principal investigators are governance group coordinator Louis A. Picard, director of the Ford Institute and a Graduate School of Public and International Affairs (GSPIA) faculty member,  and lead methodologist Steven E. Finkel, Daniel H. Wallace Professor of Political Science.

The group will oversee the conduct of surveys, interviews and focus-group discussions in each of the countries where Peace through Development operates. The Pitt group also will conduct cross-national statistical comparisons in order to monitor the program’s overall effectiveness.

The project is expected to be a significant resource for faculty and students.

“We may want to use this material in other parts of the world, in other programs,” said Picard, adding that the methodological work completed during this project could be valuable to students and other researchers.

CPR choice influenced by doctors’ words

A physician’s choice of words when talking with family members about whether to try cardiopulmonary resuscitation (CPR) if a critically ill patient’s heart stops may influence the decision, according to a study led by Amber E. Barnato, a faculty member in clinical and translational science at the School of Medicine.

Barnato and her team recruited more than 250 adult children or spouses in eight cities: Boston, Atlanta, New York, Los Angeles, San Francisco, Dallas, Denver and Pittsburgh. The participants took part in a web-based survey involving a hypothetical situation in which a loved one was in the intensive care unit with a 40 percent chance of dying from sepsis, a bacterial infection. Some subjects were shown a photo of their loved ones to help them imagine the situation and heighten the emotional response. An actor portrayed a physician who held a virtual, interactive meeting with the family member. The “doctor’s” responses varied, using different words for the same scenarios. Additionally, some people were offered emotional support and others were offered only clinical information.

A key finding was that when participants were asked to choose between having their loved ones receive CPR if their hearts should stop — a treatment with a 10 percent chance of successfully reviving them — or the alternative, a “Do Not Resuscitate” (DNR) order, 60 percent chose CPR. When the alternative was described as to “allow natural death” instead of a DNR order, the number choosing CPR dropped to 49 percent.

When the “doctor” cited “his own experience” about how most others handled such a situation, family members were more likely to choose what they believed was the common approach.

Using more empathic language did not influence CPR choice.

“Simple changes of words and perceptions about social norms resulted in large differences in CPR choices,” said Barnato. “The change in terminology from ‘DNR’ to ‘allow natural death’ already has been implemented in a health system in Texas. This study suggests that the change isn’t just window dressing  —  it makes a real difference in the choices that people make. We expect that it also may reduce feelings of guilt for choosing against CPR by making family members feel like they are doing something positive to honor their loved one’s wishes at the end of life, rather than taking something away from them.”

Robert M. Arnold, faculty member in palliative care and medical ethics at the School of Medicine, coauthored the study, which was funded by the National Institute of Nursing Research and appears in the June edition of Critical Care Medicine.

Consumers less worried about being stranded electronically

For consumers of electronic products, the risk of being “stranded” by choosing a losing, incompatible format — buying a Betamax videocassette player and seeing the VHS format attain market dominance, for example — is lessening, according to an article coauthored by Chris F. Kemerer, David M. Roderick Professor of Information Systems in the Katz Graduate School of Business and College of Business Administration.

It draws on research demonstrating that in many corners of the business world, competition among digital products is no longer ending with a single clear winner, marking a move away from business environments distinguished by “standards wars” between similar but incompatible technologies.

Kemerer, along with co-authors at Carnegie Mellon and the University of Texas-San Antonio, explained that the new business trend is creating a market for digital goods in which “winners take some” instead of “winner takes all.” Basic economic theory, the authors wrote, traditionally has predicted that markets for technologies will tip toward a single dominant standard, with competing technologies falling away. However, many technologies with multiple formats now are succeeding alongside one other.

The primary sources of this shift are digital converters — devices that accept multiple formats, thus resolving incompatibility issues. Said Kemerer: “The digital medium allows you to make conversions easily, yielding near-perfect copies. Converters are the game changer.”

Kemerer and his colleagues cited the example of Amazon, which allows users to read Amazon’s Kindle book titles both on Amazon’s Kindle digital reader and on other portable devices, including iPads and iPhones. They also point to the market for flash memory cards — storage sources that can be used interchangeably between digital cameras, mobile phones and audio players — as an example of how digital converters have changed the marketplace.

The researchers determined that the “winners-take-some” marketplace provides reasons for optimism among consumers, who increasingly are able to value product features, functionality and design features over mere platform compatibility as they did during the Betamax-versus-VHS era. There are potential advantages for firm managers, too, if they can adapt to the changing environment. Instead of pouring money into encouraging customers to choose a particular technology, anticipating a jackpot payment when the standards war has been won, firm managers should cross-license their products to increase total market size, the researchers said.

The article was published in the May issue of Communications of the ACM (Association for Computing Machinery).

HIV research could lead to treatment for bacterial infection

Researchers led by senior author Ronald Montelaro, faculty member in microbiology and molecular genetics in the Graduate School of Public Health, have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach that HIV uses to infect cells. It is especially promising in the development of a potential treatment for lung infections in people with cystic fibrosis.

Montelaro, who also is co-director of the Center for Vaccine Research (CVR), said: “The discovery of this new antibiotic was an unexpected result of basic research on HIV proteins. As a result of studying these proteins, we discovered novel structures that turn out to work very well against bacterial infections, including the complicated bacterial populations in lung infections in cystic fibrosis patients.”

Joseph M. Pilewski, faculty member in medicine, cell biology, physiology and pediatrics in the School of Medicine and co-director of the Adult Cystic Fibrosis Center at UPMC, said: “Infections with progressively resistant bacteria in the lung shorten the lives of people with cystic fibrosis. What happens is the genetic defect predisposes patients to infections that drive the production of mucus that then blocks the airways and makes it difficult to breath.”

Montelaro and his colleagues found that a particular sequence of amino acids on the tail end of HIV allows the virus to penetrate and infect cells. The team manufactured a synthetic and more efficient version of this sequence — called engineered cationic antimicrobial peptides, or “eCAPs” — that laboratory tests have shown to rapidly destroy bacteria that otherwise are resistant to most standard antibiotics.

The eCAPs can be assembled in a laboratory from the amino acids arginine and tryptophan and manufactured to the shortest effective length, giving the resulting antibiotic treatment maximum potency while reducing costs.

Pitt has taken out several U.S. and international patents on this discovery.

Co-author Yohei Doi, medicine faculty member in the School of Medicine, said: “We have an unmet clinical need for treatment of hospital-acquired infections where the bacteria are extremely resistant to antibiotics. We have patients with no treatment options left. The fact that these eCAPs are completely engineered puts them at an advantage because they can be manufactured easily, and they give us some hope for a quick-acting treatment in these dire circumstances.”

Traditional antibiotics typically work by poisoning important metabolic processes after being taken up by the target bacteria, a process that may take days, to clear a bacterial infection. In contrast, the eCAPs are specifically attracted to the surface of target bacteria where they disrupt the bacterial membrane, causing the bacteria’s death within minutes.

Tests indicate that the eCAPs work well against biofilms, which are bacterial communities that develop very high levels of resistance to antibiotics by working together to protect the film’s inner bacteria from traditional treatments. The eCAPs seem to push through the outer layers of biofilms to destroy the entire bacterial community.

Montelaro said: “While cystic fibrosis patients are our initial target and a very high-priority target, we also could look at infections associated with burns or indwelling medical devices, such as venous catheters. We could even look to the biodefense realm, in terms of a rapid, handheld nebulizer treatment that soldiers could use in the case of exposure to a bioterrorism agent.”

Other co-authors were Berthony Deslouches and Jodi Craigo of CVR and a researcher from the Lake Erie College of Osteopathic Medicine at Seton Hill.

The research was funded by the National Institutes of Health (NIH) and will be published in the June issue of Antimicrobial Agents and Chemotherapy.

Breast milk ingredient may help preemies

An ingredient that occurs naturally in breast milk might be used to prevent premature babies from developing a deadly intestinal condition that currently is largely incurable, according to researchers led by senior author David Hackam, Watson Family Professor of Surgery in the School of Medicine and co-director of the Fetal Diagnosis and Treatment Center at Children’s Hospital.
Once babies who are born before 36 weeks gestation are stable, they typically are fed with formula, because breast milk often is not readily available.

Some of these preemies develop necrotizing enterocolitis, or NEC, in which the intestinal tissue is dying. Hackam said: “We have no choice but to remove the dead parts of the intestine, but despite surgery, half of these preemie babies still die from the condition.”

Hackam and his team noted NEC occurs when the intestines begin being colonized with bacteria, a process that occurs normally after birth. They focused on toll-like receptor 4 (TLR4), an immune protein that is involved in recognizing microbes and which they recently discovered plays a role in gut development. TLR4 is present in higher amounts in the blood vessel lining in preemies than in full-term babies, the researchers found.

Using a mouse model designed to induce NEC, the study showed that, unlike normal mice, those bred to lack TLR4 in their blood vessels did not develop NEC. The findings indicate that bacteria in the blood activate TLR4, leading to a reduction in nitric oxide, which in turn narrows blood vessels and decreases blood flow, Hackam said.

“This pathway can be dangerous when the preemie’s immature gut becomes inflamed from exposure to the bacteria normally present in the intestine,” Hackam said. “Abundant TLR4 triggers a shutdown of the blood supply to the intestine, leading to tissue death or necrosis.”

According to co-author and nitric-oxide expert Mark Gladwin, chief of the Division of Pulmonary, Allergy and Critical Care Medicine at the School of Medicine, because premature babies who are nursed rather than formula-fed are more likely to survive NEC, the team took a closer look at the components of breast milk.

They found that breast milk contains high levels of sodium nitrate, which is converted to nitrite by gut bacteria. Nitrite can be directly converted to the vasodilator nitric oxide, which can both protect the intestinal lining and improve blood flow.

Said Gladwin: “The additional nitrite appears to overcome the effects of TLR4 activation and corrects the blood flow problem. When we gave formula supplemented with a sodium nitrate and nitrite analog to the premature mice, we saw improved blood flow in the intestine, and NEC did not develop.”

Hackam and Gladwin are testing the compound, which is FDA-approved for other uses, in other models of NEC with the hope that it could be added routinely to formula fed to premature infants to prevent NEC.

Co-authors of the paper included researchers from the Division of Gastroenterology and the pediatrics, pathology and surgery departments at the School of Medicine and from Children’s Hospital.

The project was funded by NIH, the Hartwell Foundation, the Institute for Transfusion Medicine and the Hemophilia Center of Western Pennsylvania.

Results appear in the current online early edition of the Proceedings of the National Academy of Sciences.

Children with disabilities growing fastest among higher-income families

More children have disabilities now than a decade ago, and the greatest increase is among children of higher-income families, according to a study led by Amy Houtrow, a faculty member in physical medicine and rehabilitation and in pediatrics at the School of Medicine.

The study also showed that while disabilities due to neurodevelopmental and mental health problems have increased sharply, disabilities related to physical health conditions have decreased. This trend was most noteworthy among children under 6 years of age whose rate of neurodevelopmental disabilities nearly doubled during the study, from 19 cases to 36 cases per 1,000 children.

Said Houtrow: “A century of health-care improvements and social changes have altered the face of childhood chronic disease and disability. Nearly six million kids were considered disabled in 2009 and 2010, almost one million more than in 2001 and 2002.”
While previous studies have found an increase in the prevalence of childhood disability, Houtrow and her research team wanted to look more closely at the specific conditions and socio-demographic factors associated with disabilities.

The researchers studied data from the National Health Interview Survey conducted by the U.S. Centers for Disease Control and Prevention (CDC) from 2001 to 2002 and from 2009 to 2010. Participants included more than 102,000 parents of children up to age 17.

The research team assembled a composite of disability indicators to identify children with disabilities and their associated underlying chronic conditions. Conditions were categorized into three groups: physical; neurodevelopmental/mental health, and other.

The overall rate of disability for children under age 18 increased 16.3 percent between the 2001-02 period and the 2009-10 period.

Children living in poverty represented the largest numbers of overall children with disability in both time periods, but not the highest growth rates. The largest increase in growth rates of disabilities was seen among children living in households with incomes at or above 300 percent of the federal poverty level, about $66,000 a year for a family of four in 2010.

“We are worried that children living in lower-income families may be having problems accessing diagnostic and treatment services,” Houtrow said.

Co-investigators were from the American Academy of Pediatrics, the University of California-San Francisco and UCLA.

Results were presented at the Pediatric Academic Societies’ annual meeting.

Plasma given  on choppers may reduce deaths

Trauma experts working under principal investigator Jason Sperry, faculty member in surgery and critical care medicine at the School of Medicine, are launching a multi-center trial to see if they can improve survival of patients who have suffered traumatic injuries with uncontrolled bleeding. Paramedics will administer plasma to these patients while they are being transported by helicopter to the hospital.

Uncontrolled bleeding is one of the leading causes of death following a traumatic injury because it can lead to multiple organ failure. The pre-hospital air medical plasma trial (PAMPer) will build on research findings that early transfusions can lower mortality and reduce the total number of blood transfusions required.

Said Sperry: “If plasma treatment proves beneficial, this study could provide a new standard of care for emergency services nationwide.”

During the four-year study, STAT MedEvac will enroll patients with blunt or penetrating trauma and hemorrhagic shock resulting from significant blood loss who are being transported to a trauma center participating in the trial. STAT MedEvac already carries red blood cells for transfusion in these patients but not plasma because of logistical issues related to coordination between helicopters and the blood bank. Plasma will be added to the helicopters in this study in one-month, randomized intervals.

“A quarter of patients with these types of traumatic injuries present with a tendency toward bleeding, which is associated with death occurring in a relatively short time,” said Sperry. “Plasma reduces bleeding. By bringing the plasma to patients before they even get to the hospital, we may reduce the potential for death.”

Because patients who have suffered these kinds of injuries are unlikely to be able to give consent to participate in the trial, the PAMPer study will be conducted under a federally authorized exception from informed consent process that includes a means to opt out of inclusion. Community members who do not wish to participate in this research study can obtain a bracelet to opt out by contacting Meghan Buck at buckml@upmc.edu.

The research, sponsored by the U.S. Department of Defense, Pitt and UPMC, will be performed at UPMC Presbyterian and five other medical centers.

Amphibians gain insecticide resistance

Amphibian populations living close to agricultural fields have become more resistant to a common insecticide and actually are resistant to multiple common insecticides, according to two studies by principal investigator Rick Relyea, faculty member in biological sciences in the Dietrich School of Arts and Sciences and director of the University’s Pymatuning Laboratory of Ecology.

In the most recent study, published this month in Evolutionary Applications, the researchers demonstrated, for the first time, that tadpoles from populations close to farm fields are more resistant to chlorpyrifos, one of the most commonly applied insecticides, often sold as “Dursban” or “Lorsban.” In addition, a related study published in February showed that tadpoles resistant to chlorpyrifos also are resistant to other insecticides.

Said Relyea: “While we’ve made a lot of progress in understanding the ecological consequences to animals that are unintentionally exposed to insecticides, the evolutionary consequences are poorly understood.”

The researchers used newly hatched tadpoles collected from nine populations of wood frogs living at different distances from agricultural fields. They tested the frogs’ resistance when exposed to chlorpyrifos, which is used against insects, and Roundup Original MAX, which is a common herbicide used against weeds.

Relyea and his Pitt collaborators exposed the tadpoles to environments containing either no pesticides, chlorpyrifos or Roundup. After 48 hours, they measured how well the populations survived.

Said Rickey Cothran, lead author of the study and a postdoctoral researcher in Relyea’s lab: “Wood frogs living close to agricultural land were more likely to have been exposed to pesticides for many generations compared to those living far from agriculture; the latter frog populations likely experienced little or no exposure to pesticides. Although populations differed in their resistance to Roundup, populations closer to fields were not more resistant to the herbicide.”

“Because chlorpyrifos kills in a way that is similar to many other insecticides, higher resistance may have been favored each time any insecticide was sprayed,” said Jenise Brown, a co-author of the study and a former undergraduate researcher in Relyea’s lab. “In contrast, herbicides have a variety of ways that they kill organisms, which may make it harder for animals to be resistant when exposed to different herbicides over many years.”

In the earlier study, published online Feb. 21 in Environmental Toxicology and Chemistry, Relyea’s research team examined whether wood frog populations that were resistant to chlorpyrifos might be resistant to other insecticides. This phenomenon, said Relyea, happens commonly in pest species when farmers switch pesticides from year to year, but little is known about how this switching of pesticides affects amphibians.

Using three commonly applied pesticides that have similar chemical properties — chlorpyrifos, carbaryl and malathion — the researchers exposed 15 populations of wood frog tadpoles to high concentrations of each insecticide. They found that wood frog populations with resistance to one insecticide also had resistance to the other insecticides.

Said Jessica Hua, the lead author of the earlier study and a graduate student in Relyea’s lab: “This has a beneficial outcome. While it doesn’t mean that pesticides are beneficial to amphibians, our work does suggest that amphibians can evolve to resist a variety of pesticides and therefore improve their survival.”

As they hypothesized in the more recent study, the researchers suspect that the reason for this cross-resistance is that chlorpyrifos kills in a way that is similar to many other insecticides. Thus, evolving higher resistance to one insecticide may provide higher resistance to others.

Funding for both studies was provided by the National Science Foundation.

Depression in late-lifeshows higher dementia risk

Late-life depression is associated with an increased risk for all-cause dementia, Alzheimer’s disease and, most predominantly, vascular dementia, according to the results of a new meta-analysis led by Meryl Butters, psychiatry faculty member in the School of Medicine and corresponding author of the study.

Previous studies have shown an association between depression and Alzheimer’s disease, but this is the first meta-analysis that specifically addresses the risk of Alzheimer’s disease and vascular dementia in older adults with late-life depression. The study, conducted with other medicine researchers at the Federal University of Minas Gerais, also is the first to show that late-life depression increases the risk of vascular dementia and that the risk of vascular dementia is greater than the risk of Alzheimer’s disease for older adults with depression.

“All-cause dementia” refers to all dementia syndromes; the most common is Alzheimer’s disease, accounting for 60-80 percent of dementia cases. Alzheimer’s disease is associated with memory problems and apathy in early stages, and impaired judgment, confusion, disorientation, behavior changes and difficulty speaking in later stages. Vascular dementia is the second most common cause of dementia, and is associated with impaired judgment or ability to plan and complete tasks.

Said Butters: “An understanding of how late-life depression increases the risk of dementia could lead to better prediction and prevention mechanisms. Early diagnosis and prevention of depression could have a major dual public-health impact as they could also potentially prevent or delay cognitive decline and dementia in older adults.”

Late-life depression is one of the most common psychiatric illnesses in older adults, affecting 15 percent of adults aged 65+ in the United States, or approximately 6 million people.

Although the symptoms of depression vary, clinical depression is characterized by an inability to function normally or complete daily tasks over a prolonged period of time.

The research evaluated 23 community-based cohort studies as part of a meta-analysis to calculate the pooled risk of all-cause dementia, Alzheimer’s disease and vascular dementia in older adults with late-life depression. The findings concluded those with late-life depression are:

• 1.85 times more likely to develop all-cause dementia;
• 1.65 times more likely to develop Alzheimer’s disease;
• 2.52 times more likely to develop vascular dementia.

The authors note that preventing depression and improving general health, including cardiovascular health, should be considered in public-health policies associated with preventing and/or delaying the onset of dementia.

The research was sponsored by the National Institute of Mental Health and the John A. Hartford Foundation Center of Excellence in Geriatric Psychiatry at UPMC. It was published in the British Journal of Psychiatry.

Computer paper tops

A paper coauthored by Alex Jones, faculty member in electrical and computer engineering and director of the computer engineering program at the Swanson School of Engineering, was named one of the top 25 most influential papers from the IEEE Field Programmable and Custom Computing Machines Conference (FCCM).

“A MATLAB compiler for distributed, heterogeneous, reconfigurable computing systems” (2000) was recognized in part for providing “a first step in the development of the MATLAB compilation tools in Xilinx System Generator that are used by thousands of engineers annually.”

FCCM is the premiere IEEE conference on field programmable computer hardware. The paper, which had 12 other co-authors, was in the top 5 percent of all papers presented at the conference over its 20-year duration.

Grants fund skin cancer research

Two University of Pittsburgh Cancer Institute researchers have been awarded grants by the Melanoma Research Alliance (MRA).

Hussein Tawbi and Hassane M. Zarour, both faculty members in the Department of Medicine,  are among 49 researchers worldwide who will share over $9.6 million in MRA grants to develop improved means to prevent, detect and treat melanoma, one of the fastest growing cancers.

Tawbi is one of three principal investigators awarded the Team Science Award to continue study of the safety and efficacy of the selective BRAF inhibitor drabafenib in melanoma patients with brain metastases. Tawbi and researchers from the University of Texas M.D. Anderson Cancer Center and Melanoma Institute Australia will receive $900,000 over three years.

Zarour received an Academic Industry Award for his study looking at therapy with anti-PD-1 antibody and Peginterferon alpha-2b for melanoma. He will receive $786,000 over three years from both Merck and MRA.

Program prevents teen dating violence

Coaching Boys Into Men (CBIM), a program that seeks to reduce dating violence and sexual assault, is effective in reducing abusive behaviors among male athletes toward their female partners, according to a year-long evaluation study led by Elizabeth Miller, faculty member in  pediatrics in the School of Medicine, which examined the long-term effectiveness of the program.

The study looked at more than 2,000 male athletes in 16 California high schools who participated in the coach-led program to prevent abuse toward women. Results demonstrated that participants were less likely to support peers’ abusive behaviors and showed a significant relative reduction in abuse perpetration.

Said Miller: “Boys who participated in the program were significantly more likely to stop abusive behaviors among their peers. Now, one year later, we find that the rates of abuse perpetration actually increased among youth who didn’t participate, whereas perpetration did not increase among the male athletes whose coaches delivered the program.”

Created by the national nonprofit Futures Without Violence in collaboration with Miller, the CBIM program works with coaches to teach their male athletes about building healthy relationships and how to intervene when witnessing disrespectful and abusive behaviors among their peers.

The program combines discussions of personal responsibility, being a positive bystander (stopping disrespectful behaviors among peers), respectful relationships and preventing technology-based bullying, and leverages the influence of athletic coaches as powerful messengers for violence prevention and male athletes as leaders in their community. Lessons focus on respect, non-violence, integrity and leadership.

The study was funded by the CDC.

Collaborators with Miller on the study were researchers from Children’s Hospital, University of California-Davis, Futures Without Violence, Johns Hopkins, University of California-San Diego and WEAVE.

Results appeared in the online version of the American Journal of Preventive Medicine.

Fracking’s perceived effects still stressors

Pennsylvania residents living near unconventional natural gas developments using hydraulic fracturing, or “fracking,” attribute several dozen health concerns and stressors to the Marcellus Shale developments in their area, according to a long-term analysis by public health researchers.

Reported health impacts persist and increase over time, even after the initial drilling activity subsides, they noted. The study did not include clinical examinations of the participants’ physical health or any environmental tests. Researchers surveyed those who believe their health has been affected by hydraulic fracturing activities for self-reported symptoms and stressors. The most commonly cited concern was stress, which 76 percent of participants said they’d experienced. Among the leading causes of stress reported by the participants were feelings of being taken advantage of, having their concerns and complaints ignored, and being denied information or misled.

Senior author Bernard Goldstein, faculty member and former dean, said: “Many of these stressors can be addressed immediately by the gas drilling industry and by government. Scientific literature shows that if people do not trust companies doing work in their communities, or believe that the government is misleading them, there is a heightened perception of risk.

“Community disruption and psychosocial stress have been well-documented as a result of environmental issues like oil spills and Superfund sites,” said Goldstein, who is a member of the National Academies’ committees to investigate shale gas drilling in the United States and Canada. “A strong response by the Pennsylvania Department of Health to address concerns about health impacts of hydrofracturing could reduce observed stress and resulting symptoms.”

From May through October 2010, members of public health’s Center for Healthy Environments and Communities conducted in-depth interviews with 33 people concerned about fracking in their communities. Three-quarters of the residents resided in five of the seven most heavily drilled counties in Pennsylvania.

Follow-up interviews were conducted January-April 2012 and included 20 of the initial 33 participants. The remainder could not be reached or declined to participate.

Said lead author and doctoral student Kyle Ferrar: “Comprehensive epidemiological studies of all potential adverse consequences of fracking need to be performed, and they should include a close look at psychosocial symptoms, including stress, which cause very real health complications.”

Participants attributed 59 unique health issues to Marcellus Shale development. In addition to stress, these perceived health issues included rashes, headaches, shortness of breath, nausea and sore throats.

Public health co-authors included Jill Kriesky, Charles Christen, Lynne Marshall, Samantha Malone, Ravi Sharma and Drew Michanowicz.

The work was funded by the Department of Environmental and Occupational Health. It appears in the May issue of the International Journal of Occupational and Environmental Health.

Grant awarded to study meds at discharge

A team from UPMC, including Amy Calabrese Donihi and Kim C. Coley, faculty in the School of Pharmacy, were awarded funding by the American Society of Health-System Pharmacists Research and Education Foundation for research on the implementation of a program that enables the dispensing of multi-dose medications to patients when they are discharged from the hospital.

After patient discharge, most hospitals discard partially used multi-dose medications, such as insulin pens and inhalers, even if the patient will be continuing the same medication at home. This practice is costly from a waste disposal perspective and it is both costly and inconvenient for the patient, who must immediately go to a pharmacy after discharge to obtain the same medication.

Hospitals typically do not send medications home with patients because it is difficult to meet the regulatory requirements of an outpatient pharmacy, such as offering pharmacist counseling. The primary goals of this project are to develop a process to overcome these barriers, implement a program to dispense partially used multi-dose medications to patients at the time of hospital discharge and demonstrate that providing this type of program improves medication access, patient satisfaction and patient outcomes.

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The University Times Research Notes column reports on funding awarded to Pitt researchers as well as findings arising from University research.

We welcome submissions from all areas of the University. Submit information via email to: utimes@pitt.edu, by fax to 412/624-4579 or by campus mail to 308 Bellefield Hall.

For submission guidelines, visit www.utimes.pitt.edu/?page_id=6807.

To the University community:

The Pitt Partnership for Food drive has been extended through Friday, May 31.

Each year for the past 27 years, the Pitt community has helped fight hunger through the Pitt Partnership for Food drives. Faculty, staff and students participate in large numbers, donating food and money during the drive, as well as by volunteering at the distribution center throughout the year. Our partner, the Greater Pittsburgh Community Food Bank, relies on our support in order to supply soup kitchens, food pantries, shelters and other outlets throughout southwestern Pennsylvania.  This network includes the Oakland Food Pantry, which was established as a Day of Caring project by the Pitt community and now serves over 600 of our neighbors in need each month.

Please consider donating at one of our many drop-off sites at major campus buildings, or conveniently online at www.pittsburghfoodbank.org/pitt.

A most important fact is that every dollar donated to the food bank helps provide five meals to those in need, and with the chancellor’s offer to match each contribution, every dollar donated through the online drive is doubled and will help provide 10 meals! This is a wonderful opportunity to double your donation dollars, or to donate cereals, canned or bottled foods, as well as sealed kitchen and laundry products.

Please call community relations at 412/624-7709 or email ksahni@pitt.edu if you need any additional information.

Thank you for your action in impacting hunger in our region!

Kannu Sahni
Community Relations

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As the University planning and budgeting committee prepares Pitt’s budget for the next academic year, “The challenges we face now are a little bit different because they’re coming at us from all three levels of government,” the chancellor told Senate Council in his May 8 report.

Nordenberg reported that an agreement between the governor and the four state-related universities to hold down tuition increases in exchange for flat-funding in the coming fiscal year appears to be holding in spite of state revenue receipts that have fallen “significantly below the projections upon which the governor’s February budget proposal was based.”

Gov. Tom Corbett’s proposed general fund budget of $28.4 billion represents an increase of nearly $679 million, or 2.4 percent, from the current fiscal year. It assumes a $544 million beginning balance based on general fund expenditures of $27.751 billion and available funds totaling $28.295 billion.

However, the state Department of Revenue stated that fiscal year-to-date general fund collections as of May 1 totaled $23.9 billion, or 0.3 percent above estimate.

The chancellor, who said he had spent several days in Harrisburg visiting with legislators earlier in the week, added, “There is likely to be a period of scrambling and perhaps a period of additional cutting before the budget for the next fiscal year is finalized. However, I saw absolutely no indications that anyone is at this point thinking about revisiting the flat-funding agreement that was reached with the state-related universities in February.” (See Feb. 7 University Times.)

Pitt’s current appropriation totals $144.34 million, including $134 million for general support and more than $2.08 million for rural education outreach, plus $4.05 million in academic medical center funding.

“The good news on the budget front, with respect to the state, is that our arrangement still appears to be in place. The other side of that news is that arrangement again keeps us at funding levels that are the equivalent, in unadjusted dollars, to the support we received in 1995.”

At the federal level, the University soon will be feeling pressure from the federal sequester, which, the chancellor said, ”most directly and most immediately will affect research funding.”

He added, “There are lots of other ways in which it could affect us as well.”

The University is estimating it could lose $32.6 million in federal research funding due to the federal cuts this fiscal year. (See March 7 University Times.)

Referring to Pittsburgh Mayor Luke Ravenstahl’s move to question UPMC’s nonprofit status, Pitt also is facing what Nordenberg called a “simmering challenge” to the nonprofit community from municipal government, which he said has been set aside in the midst of this month’s primary elections.

“For a while we had the pleasure of focusing on one as opposed to the other, but these days it really is kind of a triple threat that is coming our way,” Nordenberg said.
“The good news is that we will be dealing with all of those challenges from a position of relative strength,” the chancellor said, adding that, compared with peer institutions, “we have been more effective and maybe better equipped to deal with them.”

Declining to release specific figures, the chancellor said, “We have had a really outstanding year in terms of applications, at a time when many good schools have been facing application declines. Ours are way up, showing again that, within the marketplace, we really are viewed as a best-value institution.

“We’ll be moving forward from a position of relative strength and we also will be moving forward together.”

—Kimberly K. Barlow

They received the 2013 Grand Prize in the university research category of the AAEES Excellence in Environmental Engineering and Science Competition for a project titled “Use of Treated Municipal Wastewater as Power Plant Cooling System Makeup Water.”

Vidic, the William Kepler Whiteford Professor and Chair,  Department of Civil and Environmental Engineering at the Swanson School of Engineering, said: “We need a great deal of water for electric power production to condense steam in the power plant steam cycle. Air cooling is possible but is more costly and less efficient. Water will continue to be the preferred coolant for new thermoelectric power plants.”

The CMU-Pitt research shows that treated municipal wastewater is a common and widely available alternative source of cooling water for thermoelectric power plants across the United States. However, the biodegradable organic matter, ammonia, carbonate and phosphates in the treated wastewater pose challenges, including fouling and corrosion issues. The researchers, along with their graduate students, investigated how to address these challenges.

They  noted that their work shows the need to evaluate the growing competition among the energy industry, farmers and residents for scarce water supplies. Every day, water-cooled thermoelectric power plants in the United States withdraw more than 200 billion gallons of fresh water from rivers, lakes, streams and aquifers. Freshwater withdrawals for cooling thermoelectric power production alone account for about 40 percent of all withdrawals, essentially the same amount taken for agricultural irrigation, according to the U.S. Geological Survey.

“Our research shows that alternative sources of water are needed for new power production in regions without new sources of available freshwater,” Dzombak said. “Our research will not only help promote the use of properly treated municipal wastewater at cooling plants, but help contribute to economic development.”

*

Alberta Sbragia, vice provost for graduate studies, was recognized last week by the European Union Studies Association for her scholarship, mentoring and promotion of European Union studies.

Sbragia, who also is a faculty member in political science, received the Award for Lifetime Achievement in the Field of EU Studies.

From conducting research interviews in Brussels as Germany took the first steps toward demolishing the Berlin Wall, to publishing highly regarded research on the continent’s political processes, to mentoring generations of European Union scholars, Sbragia has influenced the field of European Union studies.

Sbragia chaired the European Union Studies Association, 1993-95. The association now is headquartered at Pitt.

“The executive committee of the European Union Studies Association was unanimous in its choice of Dr. Sbragia, given her work mentoring students, her own scholarship and also for being so instrumental in bringing the European Union Studies Association to Pittsburgh and giving it a permanent home,” said Michelle Egan, vice president of the European Union Studies Association, faculty member at American University’s School of International Service — and Sbragia’s first doctoral student. “Dr. Sbragia is very well known for promoting young scholars and doctoral students, for building up European Union studies at Pitt, and for attracting scholars and practitioners to the University,” Egan added.

Sbragia, one of the world’s foremost experts on European politics and economics and a leading authority on the teaching of international affairs, joined Pitt’s faculty in 1974, teaching American and European urban politics and policy.

In 1983, she was a visiting faculty member at Harvard; she returned to Pitt the following year to become the inaugural director of Pitt’s West European studies program, now Pitt’s European Studies Center, a post she would hold until 2010.

In 1998, she was named director of Pitt’s European Union Center, one of the original 10 such centers in the United States funded by the European Commission. In 2005, the center was elevated to the status of a European Union Center of Excellence. Sbragia served as director until 2010.

Sbragia’s strengths as a teacher and mentor have been recognized through such awards as the Jean Monnet Chair ad personam, granted in recognition of her teaching and research related to the European Union, and through the 2013 Provost’s Award for Excellence in Mentoring, the 2001 Apple for the Teacher Award, and her appointment as the inaugural holder of the Chancellor Mark A. Nordenberg Chair (2006-10).

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Jonathon Erlen, history of medicine librarian in the Health Sciences Library System (HSLS), has been appointed to the American Osler Society’s Executive Board for a three-year term.

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HSLS reference librarian Andrea Ketchum has been appointed to the Medical Library Association’s scholarly communication committee for a three-year term.

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Distinguished Professor of Atlantic History Marcus Rediker, who has written extensively about working men and women and how they shaped the nation, received the Sidney Hillman Foundation’s 2013 Sol Stetin Award for Labor History this month.

The honor recognizes an individual’s lifetime achievement in the field of labor history.

Rediker, who grew up in a working-class family in Kentucky amid mines and factories, has chronicled the lives and struggles of working people in a number of widely acclaimed books. In doing so, he is credited with expanding the scope of labor history.

His first work, “Between the Devil and the Deep Blue Sea: Merchant Seamen, Pirates and the Anglo-American Maritime World,” took the study of labor out of the factories and onto the ocean; the book told of the sailors and pirates who sailed the Atlantic in the 18th century. Using many previously unknown sources, Rediker reconstructed the social world of the poor. The book won the 1988 Merle Curti Award from the Organization of American Historians for the best work in American social history and the 1988 John Hope Franklin Prize from the American Studies Association for best interdisciplinary work in American studies.

Rediker worked with a team of scholars at the American Social History Project to write “Who Built America? Working People and the Nation’s Economy, Politics, Culture and Society, Volume 1.” This reinterpretation of American history “from the bottom up” integrates the history of community, family, gender roles, race and ethnicity into the more familiar history of politics and economic development.

Rediker cowrote “The Many-Headed Hydra: Sailors, Slaves, Commoners and the Hidden History of the Revolutionary Atlantic” and wrote “The Slave Ship: A Human History”and “The Amistad Rebellion: An Atlantic Odyssey of Slavery and Freedom.”

“The Slave Ship” won the 2008 George Washington Book Prize, cosponsored by Washington College, the Gilder Lehrman Institute of American History and Mount Vernon; the 2008 Merle Curti Award, and the James A. Rawley Prize from the American Historical Association.

All three books explore the history of workers, free and unfree, in the making of Atlantic and American history.

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School of Medicine faculty members Mike Becich and Rebecca Crowley, research associate Uma Chandran and Mike Davis, all of the Department of Biomedical Informatics in the School of Medicine, collaborated with Adrian Lee, faculty member in pharmacology and  chemical biology and director of the Women’s Cancer Research Center, and other colleagues on the project that won the award for best project at the DataWorks Big Data Showcase recently.

The project uses the UPMC Enterprise Analytics Data Warehouse to develop a personalized medicine resource that brings together genomic and phenotypic data for patients with breast cancer.

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Music faculty member Nathan Davis will receive the BNY Mellon Jazz Living Legacy Award in October at the Kennedy Center in Washington, D.C.

The director of jazz studies is retiring June 28. He took the position in 1969 and, in addition to shaping Pitt’s jazz and ethnomusicology programs, founded the annual jazz seminar and concert.

Davis has written an assortment of jazz arrangements, several books on jazz, an opera and is working on a ballet.

*

Elizabeth Arkush, faculty member in anthropology, has won the 2013 Society for American Archaeology Book Award in the scholarly category for “Hillforts of the Ancient Andes: Colla Warfare, Society, and Landscape.”

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The People of the Times column features recent news on faculty and staff, including awards and other honors, accomplishments and administrative appointments.

We welcome submissions from all areas of the University. Send information via email to: utimes@pitt.edu, by fax at 412/624-4579 or by campus mail to 308 Bellefield Hall.

For submission guidelines, visit www.utimes.pitt.edu/?page_id=6807.

Thomas C. Smitherman

Discussion is continuing about some planned faculty salary cuts in the medical school.

University Senate President Thomas C. Smitherman offered an update in his May 8 report to Senate Council and promised he would make additional comments at the group’s June meeting. In addition, the issue will be addressed at Dean Arthur S. Levine’s annual state of the medical school address on May 22.

Smitherman, who is a School of Medicine faculty member, summarized the issue in his May 8 report to Senate Council. “In recent months there have been a number of requests from tenured faculty in the School of Medicine, principally from the basic sciences, who are not also members of the University of Pittsburgh Physicians, to the tenure and academic freedom committee for guidance, advice and informal mediation about planned reductions in their salaries for next academic year. One of the most common concerns was lack of knowledge on the part of faculty members about University of Pittsburgh and School of Medicine policies and procedures on this issue,” he said, noting that the relevant documents are being posted on the School of Medicine web site.

He said the Senate’s executive committee met with Levine, who also is senior vice chancellor for the Health Sciences, last month. Smitherman said that he and past Senate president Michael Pinsky, a faculty member in the School of Medicine, who are executive committee members, offered comments on Levine’s draft of an updated statement on tenured faculty salaries and of proposed new faculty performance documents.

“Here’s my understanding of where the issue stands now,” said Smitherman. First, “There’s no guarantee of salary associated with conferral of tenure anywhere on the University of Pittsburgh campus,” he said.

Second, “Policies on tenured faculty salaries and updated performance appraisal forms represent official policies that have been, so far as we are concerned on the executive committee, approved properly according to University and School of Medicine policies and procedures.”

Third, “The role of the tenure and academic freedom committee in this regard is properly focused on providing guidance and informal mediation to faculty members about salary decisions in those cases where a salary decision or set of salary decisions is part of a pattern of conduct that, taken as a whole, may constitute, according to the University guidelines, the basis for a grievance.”

Smitherman added, “Dissatisfaction with a performance appraisal decision that is perceived to affect academic freedom is within the purview of the tenure and academic freedom committee, according to University policy.”

Maria Kovacs, secretary of the Senate’s tenure and academic freedom committee, commented that faculty have continued to be concerned both about “the lack of faculty input into the decision-making and questions about the principles of shared governance into the decision-making about salaries.”

Smitherman responded, “We continue to work to make certain to make readily available to all the faculty members of the School of Medicine all of the relevant documents.”

In addition, he said, “We also have worked hard to make certain that we understand the bylaws of the School of Medicine, which are called the plan of organization, which are on the web site.”

Smitherman continued: “In the plan of organization, the specific duties of the faculty and the executive committee seem, to my mind — obviously there can be differences of opinion — to be laid out: That the faculty are responsible for education, for the curriculum, for passing or failing students, for promoting them, for accepting them into medical school, for proposing them for graduation,” he said.

“The executive committee is indeed held to be responsible to the faculty but it also very clearly says that the executive committee is primarily responsible for the policies of the School of Medicine,” Smitherman said, adding that the rules of organization likewise state that as few as five tenured faculty members can request that a meeting of the medical school faculty be called. “None has been called in my recent memory,” he said.

Smitherman urged medical school faculty to attend Levine’s state of the medical school May 22 address, which will be at 4:30 p.m. in Scaife Hall lecture rooms 5 and 6.

The address, titled “Faculty Performance: Opportunities in a Time of Threats,” also will be streamed live through a webcast accessible at http://mediasite.cidde.pitt.edu/mediasite/Viewer/?peid=1ac4875994e64df0b5321b64fcf8cccc.

*

In other business:

• Smitherman provided an update on the planned University working group on sustainability, which will replace the Senate plant utilization and planning committee’s sustainability subcommittee.

Tentatively, plans call for the group to be made up of two faculty members nominated by the University Senate, two students nominated by student sustainability organizations with the assistance of the dean of students, two staff members and two senior administrators. Ad hoc members from inside or outside the University could be added as needed, Smitherman said.

Smitherman said the working group would meet three times per year and would make periodic reports to the public with meetings to be convened by operations staff under the direction of executive vice chancellor Jerome Cochran.

Final details are expected to be available at the Senate’s June 12 meeting, he said.

Smitherman noted other activity on Pitt sustainability efforts, citing the University’s appearance in the Princeton Review guide (see May 2 University Times) and the recent student sustainability symposium during which Pitt’s LEED projects were outlined (see April 18 University Times).

• The issue surrounding the suspension of graduate programs in German, classics and religious studies is expected to be resolved soon, Smitherman said, adding that a proposal approved by the Dietrich School of Arts and Sciences Graduate Council now is under review by the Dietrich School Council.

• David Gau, Graduate and Professional Student Government president, announced that orientation for graduate and professional students is set for Sept. 5.

Gau, a former Pitt Pathfinder, added that he is interested in starting a similar Pitt ambassador program for graduate students.

“I have a lot of passion and pride for Pitt and I really hope to share that experience with new prospective students. I found it surprising that there’s nothing like that for graduate students here at Pitt.”

—Kimberly K. Barlow

Nordenberg ranked No. 40 in last year’s survey among the heads of 190 public universities and university systems. (See May 31, 2012, University Times.) In The Chronicle’s 2011 survey, Nordenberg’s FY10 compensation placed him at No. 30 among 185 public university heads. (See April 14, 2011, University Times.)

The FY12 survey, released earlier this week, included public research universities and affiliated systems with enrollments of at least 10,000, and state flagship universities with smaller enrollments. It included 214 entries, made up of 212 chief executives at 191 public universities and systems. According to the survey’s data notes, some universities had more than one president during the 2012 fiscal year and some presidents served at more than one institution during the fiscal year.

The survey included “all individuals who served in the capacity of chief executive, including interim leaders,” and partial-year figures were reported for presidents who did not serve for the entire year. The Chronicle also publishes a separate survey on compensation for the heads of private institutions using different criteria that do not directly compare with the public executives’ pay survey.

Nordenberg’s total compensation of $628,880 included $561,500 in base compensation (89.3 percent of the total) and $67,380 in retirement benefits. It included no compensation in the remaining components: bonus pay, deferred compensation paid out, deferred compensation set aside and severance pay.

Additional benefits were a University-owned house, the value of which was not reported, and a University-owned Honda CR-V valued at $18,480.

*

Although he was fired as president of Penn State in November 2011, in the wake of the Jerry Sandusky sex-abuse scandal, Graham Spanier ranked at the top of The Chronicle of Higher Education’s FY12 survey with total compensation of more than $2.9 million. His base pay of $350,959 made up just 12.1 percent of the total, with the remainder coming from $1.248 million in deferred pay, $1.225 million in severance and $82,557 in retirement benefits.

Rounding out the top five were Auburn’s Jay Gogue, $2.54 million, including $482,070 base pay; Ohio State’s E. Gordon Gee, $1.9 million, including $830,439 base pay; George Mason’s Alan G. Merten, $1.87 million, including $427,369 base pay, and Ball State’s Jo Ann M. Gora, $984,647, including $431,244 base pay.

At the bottom of the national list were 14 leaders whose total compensation figures were for part of the fiscal year. Lowest was the $46,250 paid to Robert G. Frank, who took the helm at the University of New Mexico main campus in June 2012.

Timothy J. Donovan of the Vermont State Colleges system had the lowest full-year compensation in the survey. He ranked No. 200 with total compensation of $217,056.

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Pennsylvania institutions

Of six presidents of Pennsylvania institutions listed in the survey, Nordenberg ranked third behind Penn State’s Spanier and Temple’s Ann Weaver Hart. Hart’s total compensation of $688,073 ranked No. 20 nationally. She stepped down as Temple president in June 2012.

Rodney Erickson, who succeeded Spanier at Penn State in November 2011, ranked No. 63 nationally with total part-year compensation of $549,364. (Like most institutions in the survey, Penn State’s fiscal year is July 1-June 30.)

John C. Cavanaugh, who headed the State System of Higher Education, ranked No. 158 with total compensation of $351,427. Cavanaugh left earlier this year to become president and CEO of the 14-member Consortium of Universities of the Washington Metropolitan Area.

David J. Werner, interim president of Indiana University of Pennsylvania from August 2010 through June 2012, had the lowest pay of the six Pennsylvania leaders listed. He ranked No. 190 with total compensation of $276,279.

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The survey can be found online at chronicle.com.

—Kimberly K. Barlow

The nominees will be affirmed in their new positions at SAC’s June 12 meeting, according to SAC bylaws.

This was set to be SAC’s first election under the new bylaws, choosing officers for new offices — president, executive vice president, vice president of public relations, vice president of finance and parliamentarian — that replace the previous president, vice president of steering, vice president for marketing and communications and treasurer. It also would have been the first vote for four new committee chairs taking the place of 11 current committee leaders.

J.P. Matychak, incoming SAC president

The three current officers who chose to return will have new offices. Vice President of Steering J.P. Matychak will be president; he works as the director of career services in the College of Business Administration.

Treasurer Monica Costlow, project director and policy analyst for the Comparative Effectiveness Research Core at the Graduate School of Public Health, will be the new executive vice president.

Monika Losagio will be vice president of finance, after serving as the current vice president of marketing and communications. She works as an administrative assistant in the Department of French and Italian Languages and Literatures in the Dietrich School of Arts and Sciences.

Two other offices will be held by current committee chairs. Incoming vice president of public relations Emma Zink, now the head of the marketing and communications committee, is an academic adviser in admissions for the College of Business Administration, while parliamentarian Lynn Rosen currently is chair of the governance committee and works in CBA’s career services office as assistant director.

Two current committee leaders also are returning, taking the helm of two of the new committees. The chair of the staff relations committee, Tom Waters, has chaired the diversity and inclusion committee for SAC; he is director of information and communication services for the School of Pharmacy. Ken Doty, who will be leading the health, safety, IT and transportation committee, now is the vice chair (but only officer) of the safety and security committee. He works in computer services in the Swanson School of Engineering.

The two newcomers to SAC leadership are Tammeka Banks, department administrator in the Office of Research, who will head the operations committee, and Andrew Stephany, sponsored project assistant in the Department of Medicine, who is the new chair of the external relations committee.

—Marty Levine

All  benefits  changes must be made online. Go to www.hr.pitt.edu and select 2013–2014 Open Enrollment.

For employees who want to continue with the same selections, no action is necessary.